diff --git a/pyuno/Module_pyuno.mk b/pyuno/Module_pyuno.mk
index fac159e2ced3..3a12fc68efac 100644
--- a/pyuno/Module_pyuno.mk
+++ b/pyuno/Module_pyuno.mk
@@ -51,6 +51,12 @@ $(eval $(call gb_Module_add_check_targets,pyuno, \
     PythonTest_pyuno_pytests_testbz2 \
 ))
 
+ifeq ($(OS),MACOSX)
+$(eval $(call gb_Module_add_check_targets,pyuno, \
+    PythonTest_pyuno_pytests_testsetuptools \
+))
+endif
+
 $(eval $(call gb_Module_add_subsequentcheck_targets,pyuno, \
     PythonTest_pyuno_pytests_testcollections \
     PythonTest_pyuno_pytests_insertremovecells \
diff --git a/pyuno/PythonTest_pyuno_pytests_testsetuptools.mk b/pyuno/PythonTest_pyuno_pytests_testsetuptools.mk
new file mode 100644
index 000000000000..797aef2dac6c
--- /dev/null
+++ b/pyuno/PythonTest_pyuno_pytests_testsetuptools.mk
@@ -0,0 +1,16 @@
+# -*- Mode: makefile-gmake; tab-width: 4; indent-tabs-mode: t -*-
+#
+# This file is part of the LibreOffice project.
+#
+# This Source Code Form is subject to the terms of the Mozilla Public
+# License, v. 2.0. If a copy of the MPL was not distributed with this
+# file, You can obtain one at http://mozilla.org/MPL/2.0/.
+#
+
+$(eval $(call gb_PythonTest_PythonTest,pyuno_pytests_testsetuptools))
+
+$(eval $(call gb_PythonTest_add_modules,pyuno_pytests_testsetuptools,$(SRCDIR)/pyuno/qa/pytests,\
+    testsetuptools \
+))
+
+# vim: set noet sw=4 ts=4:
diff --git a/pyuno/qa/pytests/testsetuptools.py b/pyuno/qa/pytests/testsetuptools.py
new file mode 100644
index 000000000000..9439a1216120
--- /dev/null
+++ b/pyuno/qa/pytests/testsetuptools.py
@@ -0,0 +1,14 @@
+import os
+import unittest
+
+# tdf#161947: make sure importing setuptools works on all platforms
+class SetupToolsTest(unittest.TestCase):
+    def test_setuptools_import(self):
+        import setuptools
+
+        # use imported setuptools module for pyflakes
+        with open(os.devnull, "w") as devnull:
+            print(str(setuptools), file=devnull)
+
+if __name__ == '__main__':
+    unittest.main()